Imidazole derivatives. XXVII. Synthesis and radioprotective activity of substituted phenacylthioimidazoline and 3-phenyl-5, 6-dihydroimidazo [2, 1-B] thiazole …

MA Iradyan, RA Aroyan, AP Engoyan…

Index: Iradyan, M. A.; Aroyan, R. A.; Engoyan, A. P.; Grigoryan, G. Kh.; Nersesyan, S. E.; Panosyan, A. G. Pharmaceutical Chemistry Journal, 1994 , vol. 28, # 7 p. 455 - 458 Khimiko-Farmatsevticheskii Zhurnal, 1994 , vol. 28, # 7 p. 13 - 15

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Abstract

Compounds III are liable to keto-enol tantomerism and exist as a mixture of the ketone and hydroxybicyclic forms. The ketone form has the structure of phenacylthioimidazoline and the hydroxyb icyc l ic form that of 3 ophenyl-3-hydroxy-2, 3, 5, 6-tetrahydroimidazo [2, 1-b] thiazole: As has been demonstrated in previous reports [2, 7], the ratio of these forms depends on the nature of the benzene ring substituents.