Inhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin framework

…, MM Jimena, MC Gladys, ET Carlos, RP Carlos

Index: Garro Hugo; Manzur Jimena; Ciuffo Gladys; Tonn Carlos; Pungitore Carlos Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 3 p. 760 - 764

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Citation Number: 5

Abstract

Abstract Coumarin derivatives were prepared using natural products isolated from plants belonging in the Pterocaulon genus (Asteraceae) and commercial drugs. Some molecules have displayed interesting activity against myeloid murine leukemia virus-reverse transcriptase (MMLV-RT)(compounds 20 and 28 produced inhibition with IC 50 values of 38.62 and 50.98 μM, respectively) and Taq DNA polymerase (analogues 13 and 14 ...