Organic letters

Photochemistry on soluble polymer supports: synthesis of nucleosides

JH Zhong, A Fishman, E Lee-Ruff

Index: Zhong, Jian-Hua; Fishman, Alex; Lee-Ruff, Edward Organic Letters, 2002 , vol. 4, # 25 p. 4415 - 4417

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Citation Number: 21

Abstract

A new soluble polymer support synthesis of nucleosides is described. The photochemical ring expansion of cyclobutanones in the presence of poly (ethylene glycol)(PEG) results in polymer-supported ribosides. These photoadducts can be cleaved from the polymer under Vorbrüggen coupling conditions with TMS-protected purines and pyrimidines to give ribonucleosides. The method has been extended to include modified PEGs with dendritic ...

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