Tetrahedron Letters

Synthesis of N-arylpiperazines from aryl halides and piperazine under a palladium tri-tert-butylphosphine catalyst

M Nishiyama, T Yamamoto, Y Koie

Index: Nishiyama, Masakazu; Yamamoto, Toshihide; Koie, Yasuyuki Tetrahedron Letters, 1998 , vol. 39, # 7 p. 617 - 620

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Citation Number: 344

Abstract

A Pd P (t-Bu) 3 catalyst system has revealed very high activity and selectivity for the amination of N-(hetero) aryl halides with unprotected piperazine. A wide variety of N-(hetero) arylpiperazines could be prepared using this catalyst. Turnover numbers up to 6400mol/mol have been obtained.

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