Stereoselective direct copper-catalyzed alkenylation of oxazoles with bromoalkenes

F Besselièvre, S Piguel, F Mahuteau-Betzer…

Index: Besselievre, Francois; Mahuteau-Betzer, Florence; Grierson, David S.; Piguel, Sandrine Journal of Organic Chemistry, 2008 , vol. 73, # 8 p. 3278 - 3280

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Citation Number: 110

Abstract

A copper-catalyzed direct alkenylation of oxazoles with bromoalkenes has been developed. The method is both regio-and stereoselective and tolerates a variety of functional groups. A wide range of 2-E-vinyl-substituted oxazoles were obtained in high yields including the highly fluorescent alkaloid annuloline.

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