. beta.-Adrenergic blocking agents. V. 1-Amino-3-(substituted phenoxy)-2-propanols

AF Crowther, DJ Gilman, BJ McLoughlin…

Index: Crowther,A.F. et al. Journal of Medicinal Chemistry, 1969 , vol. 12, # 4 p. 638 - 642

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Citation Number: 27

Abstract

The epoxide I11 and chlorohydrin V intermediates were used without purification in most cases. The route via the epoxide (method A) mi5 preferred when the starting phenol contained a reactive group that might have interfered at the final stage. As in our previous workla we surmised that the chloropropanols (used in method B) in the presence of base lost HC1 to give the 1, 2-epoxypropane. Confirmation that the epoxide ring of I11 opened ...