Tetrahedron

Synthesis of substituted uracils by the reactions of halouracils with selenium, sulfur, oxygen and nitrogen nucleophiles under focused microwave irradiation

WP Fang, YT Cheng, YR Cheng, YJ Cherng

Index: Fang, Woei-Ping; Cheng, Yuh-Tsyr; Cheng, Yann-Ru; Cherng, Yie-Jia Tetrahedron, 2005 , vol. 61, # 12 p. 3107 - 3113

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Citation Number: 25

Abstract

Under microwave irradiation, the nucleophilic substitution reactions of halouracils with selenium, sulfur, oxygen and nitrogen nucleophiles was complete within several minutes with yields up to 99%. The method using microwave irradiation is superior to those conducted under conventional heating processes.