Tetrahedron

Further observations on the rhodium (I)-catalysed tandem hydrosilylation-intramolecular aldol reaction

M Freirı́a, AJ Whitehead, DA Tocher, WB Motherwell

Index: Freiria, Marta; Whitehead, Andrew J.; Tocher, Derek A.; Motherwell, William B. Tetrahedron, 2004 , vol. 60, # 11 p. 2673 - 2692

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Citation Number: 46

Abstract

The rhodium (I) catalysed tandem hydrosilylation-intramolecular aldol reaction provides a simple strategy for construction of a range of usefully functionalised five-membered rings from readily prepared 6-oxo-2-hexenoates in good yield and with good to excellent stereoselectivity. A series of silanes and rhodium catalysts have been investigated. Stereoselectivity proved to be highly dependant on the catalyst as well as on the ...

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