Tetrahedron

Synthesis of 1, 3, 5-trisubstituted-1, 2, 4-triazoles by microwave-assisted N-acylation of amide derivatives and the consecutive reaction with hydrazine hydrochlorides

J Lee, M Hong, Y Jung, EJ Cho, H Rhee

Index: Lee, Jongbok; Hong, Myengchan; Jung, Yoonchul; Cho, Eun Jin; Rhee, Hakjune Tetrahedron, 2012 , vol. 68, # 8 p. 2045 - 2051

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Citation Number: 15

Abstract

Facile and efficient procedures for the N-acylation reaction of amide derivatives with various acid anhydrides and the cyclization reaction of N-acylated amide derivatives with various hydrazine hydrochlorides were described. The reactions were carried out under microwave irradiation to give products in good yields in a few minutes. The synthesis of 1, 3, 5- trisubstituted-1, 2, 4-triazoles from benzamides can also be accomplished in a simple one- ...

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