Separation of. alpha. 1-adrenergic and N-methyl-D-aspartate antagonist activity in a series of ifenprodil compounds

BL Chenard, IA Shalaby, BK Koe…

Index: Chenard, B. L.; Shalaby, I. A.; Koe, B. K.; Ronau, R. T.; Butler, T. W.; et al Journal of Medicinal Chemistry, 1991 , vol. 34, # 10 p. 3085 - 3090

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Citation Number: 112

Abstract

Ifenprodil (1) represents a new class of N-methyl-Paspartate (NMDA) antagonist. This drug also possesses potent activity at several other brain receptors (most notably a1 adrenergic receptors). We have prepared the enantiomers and diastereomers of ifenprodil along with a series of partial structures in order to explore the basic structure activity relations within this class of compounds. From this study, it is clear that a1 adrenergic and NMDA receptor ...