Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1, 2-dione derivatives as thyroid hormone receptor β (TR-β) selective ligands

…, D Bandyopadhyay, K Soni, D Yevale, D Jogiya…

Index: Raval, Saurin; Raval, Preeti; Bandyopadhyay, Debdutta; Soni, Krunal; Yevale, Digambar; Jogiya, Digvijay; Modi, Honey; Joharapurkar, Amit; Gandhi, Neha; Jain, Mukul R.; Patel, Pankaj R. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 14 p. 3919 - 3924

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Citation Number: 7

Abstract

Design and synthesis of a novel 3-hydroxy-cyclobut-3-ene-1, 2-dione derivatives are reported and their in vitro thyroid hormone receptor selectivity has been evaluated in the thyroid luciferase receptor assay. The 3-[3, 5-dichloro-4-(4-hydroxy-3-isopropylphenoxy)- phenylamino]-4-hydroxy-cyclobut-3-ene-1, 2-dione 21 has shown selectivity towards thyroid hormone receptor β.