Three-Component Coupling Using Arynes and Aminosilanes for ortho-Selective Double Functionalization of Aromatic Skeletons

T Morishita, H Fukushima, H Yoshida…

Index: Yoshida, Hiroto; Morishita, Takami; Fukushima, Hiroyuki; Ohshita, Joji; Kunai, Atsutaka Organic Letters, 2007 , vol. 9, # 17 p. 3367 - 3370

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Citation Number: 32

Abstract

Arynes were found to couple with aminosilanes and carbonyl compounds in the presence of benzoic acid to provide 2-aminobenzhydrols. Sulfonylimines could also be applied to the reaction, enabling amino and aminomethyl moieties to be incorporated into contiguous positions of aromatic skeletons. Only a small amount of the three-component coupling product was obtained in the absence of benzoic acid, which confirms its vital role in the ...