Some novel reactions of 2??amino??4??methyloxazole with aldehydes: Aryl and alkyl hydoxymethylation at C??5

…, G Crank, S Jesdapaulpaan

Index: Khan, Humaid R.; Crank, G.; Jesdapaulpaan, S. Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 815 - 817

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Citation Number: 3

Abstract

Abstract 2-Amino-4-methyloxazole reacts with aldehydes to give products having a hydroxymethyl function at C–5. No Schiff's bases were formed. Reactions seem to be confined to 4-alkyl substituted-2-aminooxazoles as 2-aminooxazole and its 4-phenyl and 2- acetomido derivatives fail to react with aldehydes. The nature of the aldehyde affects the amount of the product formed.