Structure-based optimization of potent and selective inhibitors of the tyrosine kinase erythropoietin producing human hepatocellular carcinoma receptor B4 (EphB4)

K Lafleur, D Huang, T Zhou, A Caflisch…

Index: Journal of Medicinal Chemistry, , vol. 52, # 20 p. 6433 - 6446

Full Text: HTML

Citation Number: 67

Abstract

... Journal of Medicinal ... Here, we present a medicinal chemistry campaign aimed at improving the affinity of the micromolar hits 3 and 4 identified by in silico ... Chemical synthesis of about 30 derivatives of 3 and 4 yielded six nanomolar inhibitors, one of which (compound 66) has an ...

3-Substituted xanthines as promising candidates for quadruplex formation: computational, synthetic and analytical studies

[New Journal of Chemistry, , vol. 35, # 2 p. 476 - 482]

Easy preparative scale syntheses of labelled xanthines: caffeine, theophylline and theobromine

[Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 50, # 1 p. 33 - 41]

Structure-activity relationships in a series of xanthine derivatives with antibronchoconstrictory and bronchodilatory activities

[European Journal of Medicinal Chemistry, , vol. 25, # 8 p. 653 - 658]

3-Methylxanthosine: Synthesis and acidic hydrolysis of the glycosyl bond.

[Chemical & Pharmaceutical Bulletin, , vol. 37, # 5 p. 1235 - 1238]

3-Methylxanthosine: Synthesis and acidic hydrolysis of the glycosyl bond.

[Chemical & Pharmaceutical Bulletin, , vol. 37, # 5 p. 1235 - 1238]

Structure-based optimization of potent and selective inhibitors of the tyrosine kinase erythropoietin producing human hepatocellular carcinoma receptor B4 (EphB4)

Abstract

Related Articles:

More Articles...