Enantioselective total synthesis of FR900482

…, M Kambe, H Tokuyama, T Fukuyama

Index: Kambe, Mika; Arai, Eri; Suzuki, Masashi; Tokuyama, Hidetoshi; Fukuyama, Tohru Organic Letters, 2001 , vol. 3, # 16 p. 2575 - 2578

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Citation Number: 34

Abstract

The development of two approaches for the enantioselective total synthesis of FR900482 is described. A precursor for the formation of the benzazocine ring was assembled effectively by a modification of the Sonogashira coupling of an aryl triflate with a chiral acetylene unit derived from tartaric acid and the subsequent novel ketone formation via conjugate addition of pyrrolidine to the o-nitrophenylacetylene derivative. The first-generation approach to the ...