γ-hydroxypropylation of 2, 6-dialkyl (aryl) phenols with allyl alcohol and its derivatives
…, TB Khlebnikova, NI Nogina, VI Mamatyuk
Index: Krysin; Khalikova; Khlebnikova; Nogina; Mamatyuk Russian Journal of General Chemistry, 2010 , vol. 80, # 11 p. 2290 - 2297
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Abstract
Abstract The composition of the products of the reaction of 2, 6-disubstituted phenols with allyl alcohol and its derivatives in an alkaline medium was investigated, the conditions for carrying out the reaction with the predominant formation of 4-(3-hydroxypropyl)-2, 6-dialkyl (aryl) phenols were found, and its mechanism was suggested. The reaction was examined on an industrial scale. An important result is the practical demonstration of alkaline ...
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[Bebbington, David; Monck, Nathaniel J. T.; Gaur, Suneel; Palmer, Alan M.; Benwell, Karen; Harvey, Victoria; Malcolm, Craig S.; Porter, Richard H. P. Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2779 - 2782]