(9H??Fluoren??9??yl) methanesulfonyl (Fms): An Amino Protecting Group Complementary to Fmoc

Y Ishibashi, K Miyata, M Kitamura

Index: Ishibashi, Yoshitaka; Miyata, Kengo; Kitamura, Masato European Journal of Organic Chemistry, 2010 , # 22 p. 4201 - 4204

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Citation Number: 3

Abstract

Abstract A sulfonamide-based protecting group (PG),(9H-fluoren-9-yl) methanesulfonyl (Fms), which can be used in a similar way to the well-established Fmoc PG, was developed. The advantages of this new PG were demonstrated in the successful formation of a phosphonamide between an N-Fms-protected α-phosphonoalanine monoester and secondary alkylamines, including (R)-2-phenylethylamine,(S)-phenylalanine tert-butyl ...