Tetrahedron

Efficient synthesis of pyrroles and 4, 5, 6, 7-tetrahydroindoles via palladium-catalyzed oxidation of hydroxy-enamines

…, T Mizusaki, M Shishikura, T Komine, T Yoshinaga…

Index: Aoyagi, Yutaka; Mizusaki, Toshihiko; Shishikura, Masahiro; Komine, Takashi; Yoshinaga, Tokuji; Inaba, Haruko; Ohta, Akihiro; Takeya, Koichi Tetrahedron, 2006 , vol. 62, # 36 p. 8533 - 8538

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Citation Number: 12

Abstract

Facile and one-pot synthetic route of poly-substituted pyrroles and 4-oxo-4, 5, 6, 7- tetrahydroindoles is established, which consists of three steps:(1) palladium-catalyzed oxidation of hydroxy-enamines by using tetrakis (triphenylphosphine) palladium and mesityl bromide oxidation system,(2) intramolecular cyclization, and (3) dehydration.

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