Tffh as a useful reagent for the conversion of carboxylic acids to anilides, hydrazides and azides

A El-Fahm, M Abdul-Ghani

Index: El-Faham; Abdul-Ghani Organic Preparations and Procedures International, 2003 , vol. 35, # 4 p. 369 - 374

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Citation Number: 7

Abstract

N-Protected amino acid fluorides are stable and powerful acylating reagents for peptide formation for both solution and solid phase peptide synthesis.'Such acid fluorides are more stable than the corresponding chlorides towards neutral oxygen nucleophiles such as water and methanol and yet appear to be of equal reactivity towards anionic nucleophiles and amines.* Recently, tetramethylfluoroformamidinium hexafluorophosphate (TFFH, 1) was ...