Steroidal 3, 5-dienes

PM Weintraub, PL Tiernan, HD Benson…

Index: Weintraub; Tiernan; Benson; Grunwell; O'Neal Johnston; Petrow Journal of Medicinal Chemistry, 1976 , vol. 19, # 12 p. 1395 - 1399

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Citation Number: 2

Abstract

The function of the carbonyl moiety at C-3 of steroid hormones in eliciting biological responses has been the subject of some study in this1 and other lab~ ratories.~~~ In the course of our search for claudogenic steroids, we needed to prepare estr-4-ene-3a, l7/3-diol by reduction of 19-nortestosterone with LiAlH4. Purification of the crude product gave estr-4- ene-3/3, 17P-diol and estra-3, 5-dien-

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