The cinnamyloxycarbonyl group as a new amino-protecting group

H Kinoshita, K Inomata, T Kameda, H Kotake

Index: Kinoshita, Hideki; Inomata, Katsuhiko; Kameda, Takuo; Kotake, Hiroshi Chemistry Letters, 1985 , p. 515 - 518

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Citation Number: 6

Abstract

A new urethane-type protecting group for amines, cinnamyloxycarbonyl (Coc) group, is described. The cleavage of the Coc group is effectively catalyzed by 5 mol% of [Pd (PPh 3) 4] in the presence of formic acid, pyridine, and N-hydroxysuccinimide in refluxing THF. The Z- and Boc-protecting groups are not affected under the same reaction conditions.