Enzymatic pO-methylation by catechol O-methyl transferase

S Senoh, J Daly, J Axelrod…

Index: Senoh et al. Journal of the American Chemical Society, 1959 , vol. 81, p. 6240,6241

Full Text: HTML

Citation Number: 94

Abstract

The enzymatic methylation by catechol 0-methyl transferase of 3, 4-dihydroxyacetophenone (III), 3, 4-dihydroxyphenylmethylcarbinol (V) and 3, 4-dihydroxyphenethylamine (dopamine, VI) has been studied as a function of pH. Spectrophotometric, colorimetric and chromatographic methods have been developed for the assay and resolution of 0-and p-0- methylation mixtures. Depending on the nature of the side chain, p-0-methylation has ...