Tetrahedron letters

Pyridazines. Part 34: Retro-ene-assisted palladium-catalyzed synthesis of 4, 5-disubstituted-3 (2H)-pyridazinones

E Sotelo, A Coelho, E Raviña

Index: Sotelo, Eddy; Coelho, Alberto; Ravina, Enrique Tetrahedron Letters, 2003 , vol. 44, # 24 p. 4459 - 4462

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Citation Number: 28

Abstract

The efficient one-pot bis-functionalization of the 4, 5-positions of the 3-pyridazinone ring has been performed using Suzuki, Sonogashira and Stille cross-coupling reactions assisted by a retro-ene fragmentation. This route allows access in a shorter synthetic sequence to several pharmacologically useful 3 (2H)-pyridazinones.