Phosphonates α-lithies agents de transfert fonctionnel. Preparation de phosphonates α-amides et d'amides α, β-insatures, α-substitues

MK Tay, E About-Jaudet, N Collignon, P Savignac

Index: Tay, M.K.; About-Jaudet, E.; Collignon, N.; Savignac, P. Tetrahedron, 1989 , vol. 45, # 14 p. 4415 - 4430

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Citation Number: 31

Abstract

Lithiated anions (9) or (10) of secondary or tertiary α-amidophosphonates are prepared either by reaction between an α-phosphonyl carbanion and an isocyanate or a carbamate (first strategy), or by condensation of an amide enolate with diethylchlorophosphate (second strategy). Acidic hydrolysis of (9) or (10) gives α-amidophosphonate (1) alkylated or not in the α-position.(9) and (10) react with aromatic or aliphatic aldehydes to produce α, β- ...