One-pot synthesis of α-diazo-β-hydroxyesters under phase-transfer catalysis and application to the catalytic asymmetric aldol reaction

S Arai, K Hasegawa, A Nishida

Index: Arai, Shigeru; Hasegawa, Kazuya; Nishida, Atsushi Tetrahedron Letters, 2004 , vol. 45, # 5 p. 1023 - 1026

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Citation Number: 31

Abstract

The one-pot (three steps) synthesis of α-diazo-β-hydroxyesters from tosyl chloride under phase-transfer catalysis is described. The catalytic asymmetric aldol reaction between a diazoester and aldehydes was also investigated and gave moderate to good enantioselectivity.