Design and synthesis of novel spirocyclopropyl cyclohexane-1, 3-diones and-1, 3, 5-triones for their incorporation into potent HPPD inhibitors

…, A De Mesmaeker, A Mallinger, M Baalouch, A Goetz

Index: Beaudegnies, Renaud; De Mesmaeker, Alain; Mallinger, Aurelie; Baalouch, Myriam; Goetz, Andre Tetrahedron Letters, 2010 , vol. 51, # 20 p. 2741 - 2744

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Citation Number: 8

Abstract

We report the design and the efficient synthesis of novel spirocyclopropyl cyclohexane-1, 3- dione and-1, 3, 5-trione units to be incorporated into potent HPPD inhibitors. New routes involving original combinations of synthetic equivalents of α-cyclopropyl ketone-α-anion and α-cyclopropyl ester-β-cation are described.