Molecules

Synthesis of functionalised nucleosides for incorporation into nucleic acid-based serine protease mimics

MA Catry, A Madder

Index: Catry, Mieke A.; Madder, Annemieke Molecules, 2007 , vol. 12, # 1 p. 114 - 129

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Citation Number: 14

Abstract

Enzymes are of great importance in nature because of their ability to catalyse reactions in a selective and efficient way. The development of artificial catalysts which mimic enzymatic activity has always been a very challenging area of research. Among the different enzymes, proteases have been intensively studied because of their unequalled capacity for hydrolysing amide and peptide bonds under mild conditions. One of the most studied serine proteases is α-chymotrypsin, and X- ...