The Interaction of Heteroaryl??Acrylates and Alanines with Phenylalanine Ammonia??Lyase from Parsley

C Paizs, A Katona, J Rétey

Index: Paizs, Csaba; Katona, Adrian; Retey, Janos Chemistry - A European Journal, 2006 , vol. 12, # 10 p. 2739 - 2744

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Citation Number: 29

Abstract

Abstract Acrylic acids and alanines substituted with heteroaryl groups at the β-position were synthesized and spectroscopically characterized (UV, HRMS, 1 H NMR, and 13 C NMR spectroscopy). The heteroaryl groups were furanyl, thiophenyl, benzofuranyl, and benzothiophenyl and contained the alanyl side chains either at the 2-or 3-positions. While the former are good substrates for phenylalanine ammonia-lyase (PAL), the latter ...