Facile, Selective, and Regiocontrolled Synthesis of Oxazolines and Oxazoles Mediated by ZnI2 and FeCl3

…, JS Hsiao, JK Vandavasi, CY Chen, JJ Wang

Index: Senadi, Gopal Chandru; Hu, Wan-Ping; Hsiao, Jia-Shing; Vandavasi, Jaya Kishore; Chen, Chung-Yu; Wang, Jeh-Jeng Organic Letters, 2012 , vol. 14, # 17 p. 4478 - 4481

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Citation Number: 57

Abstract

An expedient method for a direct approach to the selective and regiocontrolled synthesis of 2-oxazolines and 2-oxazoles mediated by ZnI2 and FeCl3 is described. A Lewis acid promoted cyclization of acetylenic amide with various functionalities was well tolerated to give 2-oxazolines and 2-oxazoles in good to excellent yields under mild reaction conditions.