Psychotropic drugs. 18. Synthesis and structure-activity relations of 5-phenyl-1, 3-dihydro-2H-thieno [2, 3-e][1, 4] diazepin-2-ones

M Nakanishi, T Tahara, K Araki, M Shiroki…

Index: Nakanishi,M. et al. Journal of Medicinal Chemistry, 1973 , vol. 16, p. 214 - 219

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Citation Number: 54

Abstract

synthesis of inhibitors 34-40, has already been described.'The basecatalyzed ester hydrolysis was modified by using aqueous DMSO in place of aqueous MeOH. In this medium the reaction was essentially complete in 1 hr at 80-85", with yields of up to 79% being obtained. N-Arylamides (Method A). Conversion of the nitro-substituted acid to the acid chloride and condensation with the arylamine in toluene at reflux was performed as ...

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