Journal of fluorine chemistry

Synthesis of 4, 6-disubstituted pyrimidines via Suzuki and Kumada coupling reaction of 4, 6-dichloropyrimidine

F Qing, R Wang, B Li, X Zheng, WD Meng

Index: Qing, Feng-ling; Wang, Ruowen; Li, Benhan; Zheng, Xing; Meng, Wei-Dong Journal of Fluorine Chemistry, 2003 , vol. 120, # 1 p. 21 - 24

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Citation Number: 25

Abstract

The realization of the biochemical importance of nucleic acids has occasioned a great revival of interest in the chemistry of pyrimidines. Among them, substituted pyrimidines have become increasingly important as biologically interesting compounds, materials and ligands in molecular recognition [1]. The traditional methods for the synthesis of substituted pyrimidines were based on the condensation reactions of 1,3-dicarbonyl compounds (and synthetic equivalents) ...

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