Tetrahedron Letters

Pyridazines. Part 25: Efficient and selective deprotection of pharmacologically useful 2-MOM-pyridazinones using Lewis acids

E Sotelo, A Coelho, E Ravina

Index: Sotelo, Eddy; Coelho, Alberto; Ravina, Enrique Tetrahedron Letters, 2001 , vol. 42, # 49 p. 8633 - 8636

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Citation Number: 23

Abstract

An efficient and selective procedure for the cleavage of a methoxymethyl group at the 2- position in acid-sensitive pyridazinones is presented. Deprotection with Lewis acids (boron tribromide or aluminium chloride) affords 3 (2H)-pyridazinones under mild conditions without affecting multiple bonds in substituents.

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