Palladacycle mediated synthesis of cyano-functionalized chiral 1, 2-diphosphine and subsequent functional group transformations

M Yuan, SA Pullarkat, Y Li, PH Leung

Index: Yuan, Mingjun; Pullarkat, Sumod A.; Li, Yongxin; Leung, Pak-Hing Journal of Organometallic Chemistry, 2011 , vol. 696, # 4 p. 905 - 912

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Abstract

Cyano-functionalized allylic phosphine substrates containing the ortho-metalated (R)-(1- (dimethylamino) ethyl) naphthalene as the chiral auxiliary were synthesized from bromoacetaldehyde dimethylacetal via a one-pot process. The diastereoselective hydrophosphination reactions of the cis-and trans-allylic phosphine substrates gave the cyano-functionalized chiral 1, 2-bis (diphenylphosphino) ethane products with high yield ...