The Journal of Organic Chemistry

Synthesis of a novel class of peptides: dilactam-bridged tetrapeptides

NJ Manesis, M Goodman

Index: Manesis, Nick J.; Goodman, Murray Journal of Organic Chemistry, 1987 , vol. 52, # 24 p. 5331 - 5341

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Citation Number: 34

Abstract

The investigation of the secondary structures of proteins and polypeptides has been met with extensive interest in recent years. 1-6 However, because of the complexity of many naturally occurring molecules it has been necessary to study synthetic model Such model compounds are usually designed to limit the degree of conformational freedom about the peptide backb~ ne.~ J~ This limited flexibility, thus, facilitates the interpretation of ...