Preliminary structure–antiangiogenic activity relationships of 4-senecioyloxymethyl-6, 7-dimethoxycoumarin

NH Nam, Y Kim, YJ You, DH Hong, HM Kim…

Index: Nam, Nguyen-Hai; Kim, Yong; You, Young-Jae; Hong, Dong-Ho; Kim, Hwan-Mook; Ahn, Byung-Zun Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 17 p. 2345 - 2348

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Citation Number: 30

Abstract

Through a systematic modification of the novel angiogenesis inhibitor 4-senecioyloxymethyl- 6, 7-dimethoxycoumarin (1) we found that a 6, 7-dimethoxy moiety is important for bioactivity of 1. Replacement of the lactone functionality in coumarin 1 by an amide decreased its activity. By substitution of the senecioyl chain with various cinnamoyl groups we discovered 6d, bearing a 4-methoxycinnamoyl instead of senecioyl side chain, with inhibitory activity ...

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