N-Heterocyclization of primary amines with dihalides using microreactors

H He, Q Lin, X Liu, Y Yang, Y Zhou, Y Jia…

Index: He, Hongjie; Lin, Qi; Liu, Xiaofeng; Yang, Yongtai; Zhou, Yaming; Jia, Yu; Gao, Xiang Synthetic Communications, 2012 , vol. 42, # 17 p. 2512 - 2525

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Abstract

Recently, the use of microreactors for organic reactions has drawn a lot of attention. [ 1-3 View all references ] The typical dimensions of microreactors are in the range of 10–500 µm. Because of this microstructure and high surface-area–to–volume ratio, it has particularly excellent heat and mass transfer characteristics. [ 4 4. (a) Iwasaki , T. ; Yoshida , J. Macromolecules 2005 , 38 , 1159 – 1163 ; (b) Razzaq , T. ; Kappe , CO Chem. Asian J. 2010 , 5 , 1274 – 1289 . [ ...

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