Synthesis of Novel g-Ketoesters from Succinic Anhydride

M Iqbal, IB Baloch, MK Baloch

Index: Iqbal, Muhammad; Baloch, Imam Bakhsh; Baloch, Musa Kaleem Asian Journal of Chemistry, 2013 , vol. 25, # 17 p. 9701 - 9703

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Citation Number: 2

Abstract

Abstract Four alkyl g-ketohexanoates (3a-3d) have been prepared from succinic anhydride employing a three step reaction strategy. In the first step using p-toluene sulfonic acid as catalyst, the ring of succinic anhydride was opened with isopropyl, isobutyl, isopentyl and benzyl alcohols, respectively to form alkyl hydrogen succinates (1a-1d). In the 2nd step these alkyl hydrogen succinates on treatment with SOCl2 yielded 4-alkoxy-4-ketobutanoyl ...