Identification of chemokine receptor CCR4 antagonist

…, J Somerville, C Burke, C Seachord, W Vaccaro…

Index: Purandare, Ashok V.; Gao, Aiming; Wan, Honghe; Somerville, John; Burke, Christine; Seachord, Carrie; Vaccaro, Wayne; Wityak, John; Poss, Michael A. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2669 - 2672

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Citation Number: 40

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The present study reports the identification and hits to leads optimization of chemokine receptor CCR4 antagonists. Compound 12 is a high affinity, non-cytotoxic antagonist of CCR4 that blocks the functional activity mediated by the receptor. ... The present study reports the identification ...

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