… biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17α-hydroxylase/17, 20-lyase (P- …

S Ahmed, I Shahid, S Dhanani, CP Owen

Index: Ahmed, Sabbir; Shahid, Imran; Dhanani, Sachin; Owen, Caroline P. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 16 p. 4698 - 4701

Full Text: HTML

Citation Number: 9

Abstract

We report the synthesis and biochemical evaluation of a range of 4-sulfonated derivatives of 4-hydroxybenzyl imidazole which has been targetted against the two components of 17α- hydroxylase/17, 20-lyase (P-45017α), namely, 17α-hydroxylase (17α-OHase) and 17, 20- lyase (lyase). The results from the biochemical testing suggest that the compounds synthesised are highly potent inhibitors possessing excellent selectivity towards the lyase ...

Related Articles:

Synthesis and characterisation of NS13558: a new important tool for addressing KCa1. 1 channel function ex vivo

[Andreini; Biagi; Giorgi; Livi; Scartoni Farmaco, 1989 , vol. 44, # 9 p. 831 - 841]

Some benzyl-substituted imidazoles, triazoles, tetrazoles, pyridinethiones, and structural relatives as multisubstrate inhibitors of dopamine. beta.-hydroxylase. 4. …

[Kruse, Lawrence I.; Kaiser, Carl; DeWolf, Walter E.; Finkelstein, Joseph A.; Frazee, James S.; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 781 - 789]

More Articles...