alpha??phenylpropionic acid derivatives. Synthesis and dethiation of 5??benzoylbenzo [b] thiophene??3??carboxylic acid

M Hannoun, D Kolbah, N Blaževié…

Index: Hannoun, Mohammad; Blazevic, Nikola; Kolbah, Dragutin; Mihalic, Mladen; Kajfez, Franjo Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1131 - 1136

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Citation Number: 17

Abstract

Abstract The total synthesis of the title compound 8 started with p-thiocresol which was acylated with oxalyl chloride to give compound 1. This product underwent a condensation reaction with chloroacetic acid under basic conditions yielding compound 2. Two different synthetic pathways were used to convert compound 2 into the title compound 8. The first consisted in decarboxylation of 2 to 3, which was then converted to the ester 4, which was ...