Studies toward novel peptidomimetic inhibitors of thioredoxin–thioredoxin reductase system

…, A Redzej, J Golab, R Ostaszewski

Index: Klossowski, Szymon; Muchowicz, Angelika; Firczuk, Malgorzata; Swiech, Marta; Redzej, Adam; Golab, Jakub; Ostaszewski, Ryszard Journal of Medicinal Chemistry, 2012 , vol. 55, # 1 p. 55 - 67

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Citation Number: 13

Abstract

Thioredoxins (Trx) are ubiquitous multifunctional low-molecular weight proteins that together with thioredoxin reductases (TrxR) participate in the maintenance of protein thiol homeostasis in NADPH-dependent reactions. An increasing number of data reveal that the Trx–TrxR system is an attractive target for anticancer therapies. In this work, we have elaborated a new and simple synthetic approach employing Ugi reaction to synthesize ...