Discovery of inhibitors of Burkholderia pseudomallei methionine aminopeptidase with antibacterial activity

…, CG Campos, MW Henderson, Z Zhang…

Index: Bhat, Shridhar; Shim, Joong Sup; Zhang, Feiran; Chong, Curtis Robert; Liu, Jun O. Organic and Biomolecular Chemistry, 2012 , vol. 10, # 15 p. 2979 - 2992

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Citation Number: 6

Abstract

Evaluation of a series of MetAP inhibitors in an in vitro enzyme activity assay led to the first identification of potent molecules that show significant growth inhibition against Burkholderia pseudomallei. Nitroxoline analogues show excellent inhibition potency in the BpMetAP1