(Acyloxy) benzophenones and (acyloxy)-4-pyrones. A new class of inhibitors of human neutrophil elastase

…, JR Deason, A Nakao, MA Stealey…

Index: Miyano, Masateru; Deason, James R.; Nakao, Akira; Stealey, Michael A.; Villamil, Clara I.; et al. Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 1052 - 1061

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Citation Number: 17

Abstract

A series of 4-(acyloxy)-and 4, 4'-bis (acy1oxy) benzophenones were synthesized. Some of them, pivalates (trimethylacetates) and isobutyrates in particular, were found to be potent and selective inhibitors of human neutrophil (leukocyte) elastase. A series of 2-[(acyloxy) methyl]-5-(acyloxy)-4-pyrones were synthesized regioselectively from kojic acid. The 4- pyrones bearing a long chain acyl group at the 2-position and either pivaloyloxy or ...