Uracil-and thymine-substituted thymidine and uridine derivatives

AM Costa, M Faja, J Farràs, J Vilarrasa

Index: Costa, Anna M.; Faja, Montserrat; Farras, Jaume; Vilarrasa, Jaume Tetrahedron Letters, 1998 , vol. 39, # 13 p. 1835 - 1838

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Citation Number: 17

Abstract

The four possible 3′-uracil-1-yl and 3′-thymin-1-yl derivatives of 3′-deoxythymidine and the four analogous derivatives of 2′-deoxyuridine have been synthesised from thymidine and uridine, respectively. Advantages of the 2-(methoxycarbonyl) vinyl group to prevent the formation of anhydronucleosides and of SnCl2/PhSH/Et3N in relation to H2/Pd for the reduction of most azido groups are disclosed.