β-Lactam derivatives as inhibitors of human cytomegalovirus protease

…, J Naud, JA O'Meara, R Plante, R Déziel

Index: Yoakim, Christiane; Ogilvie, William W.; Cameron, Dale R.; Chabot, Catherine; Guse, Ingrid; Hache, Bruno; Naud, Julie; O'Meara, Jeff A.; Plante, Raymond; Deziel, Robert Journal of Medicinal Chemistry, 1998 , vol. 41, # 15 p. 2882 - 2891

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Citation Number: 92

Abstract

The development of novel monobactam inhibitors of HCMV protease incorporating a carbon side chain at C-4 and a urea function at N-1 is described. Substitution with small groups at the C-3 position of the β-lactam ring gave an increase in enzymatic activity and in stability; however, a lack of selectivity against other serine proteases was noted. The use of both tri- and tetrasubstituted urea functionalities gave effective inhibitors of HCMV protease. ...

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