Imidazopyridine/pyrrole and hydroxybenzimidazole/pyrrole pairs for DNA minor groove recognition

D Renneberg, PB Dervan

Index: Renneberg, Dorte; Dervan, Peter B. Journal of the American Chemical Society, 2003 , vol. 125, # 19 p. 5707 - 5716

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Citation Number: 94

Abstract

The DNA binding properties of fused heterocycles imidazo [4, 5-b] pyridine (Ip) and hydroxybenzimidazole (Hz) paired with pyrrole (Py) in eight-ring hairpin polyamides are reported. The recognition profile of Ip/Py and Hz/Py pairs were compared to the five- membered ring pairs Im/Py and Hp/Py on a DNA restriction fragment at four 6-base pair recognition sites which vary at a single position 5'-TGTNTA-3', where N= G, C, T, A. The Ip/ ...