Synthesis

The Direct Synthesis of Unsymmetrical Vicinal Diamines from Terminal Alkynes: A Tandem Sequential Approach for the Synthesis of Imidazolidinones

AV Lee, M Sajitz, LL Schafer

Index: Lee, Alison V.; Sajitz, Melanie; Schafer, Laurel L. Synthesis, 2009 , # 1 p. 97 - 104

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Citation Number: 15

Abstract

Abstract The combination of titanium-catalyzed anti-Markovnikov hydroamination of terminal alkynes with the Strecker reaction is used in the synthesis of unsymmetrical vicinal diamines via the one-pot synthesis of α-cyanoamines. This methodology is further applied to the efficient synthesis of imidazolidinones. An easy-to-use bis (amidate) titanium precatalyst permits efficient approaches to heterocyclic chemistry from terminal alkynes.

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