Synthesis and biological activities of new furo [3, 4-b] carbazoles: Potential topoisomerase II inhibitors

…, B Biannic, A Chilloux, E Vedrenne, B Baldeyrou…

Index: Hajbi, Youssef; Neagoie, Cleopatra; Biannic, Berenger; Chilloux, Aurelie; Vedrenne, Emeline; Baldeyrou, Brigitte; Bailly, Christian; Merour, Jean-Yves; Rosca, Sorin; Routier, Sylvain; Lansiaux, Amelie European Journal of Medicinal Chemistry, 2010 , vol. 45, # 11 p. 5428 - 5437

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Citation Number: 28

Abstract

New 1, 5-Dihydro-4-(substituted phenyl)-3H-furo [3, 4-b] carbazol-3-ones were synthesised via a key step Diels–Alder reaction under microwave irradiation. 3-Formylindole was successfully used in a 6-step synthesis to obtain those complex heterocycles. The Diels– Alder reaction generating the carbazole ring was optimised under thermal conditions or microwave irradiation. After cleavage of functional groups, DNA binding, topoisomerase ...