Identification of a novel class of orally active pyrimido [5, 4-3][1, 2, 4] triazine-5, 7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory …

…, JA Sergi, K Wang, Y Peng, M Renzetti, R Boyce…

Index: Guertin, Kevin R.; Setti, Lina; Qi, Lida; Dunsdon, Rachel M.; Dymock, Brian W.; Jones, Philip S.; Overton, Hilary; Taylor, Mathew; Williams, Glyn; Sergi, Joseph A.; Wang, Karen; Peng, Ying; Renzetti, Marcia; Boyce, Rogely; Falcioni, Fiorenza; Garippa, Ralph; Olivier, Andree R. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 17 p. 2895 - 2898

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Citation Number: 43

Abstract

A novel series of orally active pyrimido [5, 4-3][1, 2, 4] triazine-5, 7-diamine-based hypoglycemic agents have been identified. These compounds show non-selective inhibitory properties against a panel of protein tyrosine phosphatases including PTP1B. Compounds 12 and 13 display oral glucose lowering effects in ob/ob mice.