Tetrahedron

Conformational properties of O-alkylated benzamides

P Prabhakaran, V Azzarito, T Jacobs, MJ Hardie…

Index: Prabhakaran, Panchami; Azzarito, Valeria; Jacobs, Tia; Hardie, Michaele J.; Kilner, Colin A.; Edwards, Thomas A.; Warriner, Stuart L.; Wilson, Andrew J. Tetrahedron, 2012 , vol. 68, # 23 p. 4485 - 4491

Full Text: HTML

Citation Number: 18

Abstract

In this article, we report the synthesis, solid-state and solution-state conformational studies of O-alkylated aromatic benzamides based on two scaffolds. Intramolecular hydrogen bonding provides conformational pre-organization and side chains can interact with each other within a molecule. In the solid-state three-dimensional arrangement, the molecules further interact with each other through non-covalent interactions. Given, the demonstrated potential of ...

Related Articles:

Specific Detection and Imaging of Enzyme Activity by Signal??Amplifiable Self??Assembling 19F MRI Probes

[Matsuo, Kazuya; Kamada, Rui; Mizusawa, Keigo; Imai, Hirohiko; Takayama, Yuki; Narazaki, Michiko; Matsuda, Tetsuya; Takaoka, Yousuke; Hamachi, Itaru Chemistry - A European Journal, 2013 , vol. 19, # 38 p. 12875 - 12883]

Design and synthesis of novel CCR3 antagonists

[Gong, Leyi; Hogg, J. Heather; Collier, James; Wilhelm, Robert S.; Soderberg, Carol Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3597 - 3600]

Synthesis, structure–activity relationship, and p210 bcr-abl protein tyrosine kinase activity of novel AG 957 analogs

[Kaur, Gurmeet; Narayanan, Ven L.; Risbood, Prabhakar A.; Hollingshead, Melinda G.; Stinson, Sherman F.; Varma, Ravi K.; Sausville, Edward A. Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 5 p. 1749 - 1761]

More Articles...